Tesamorelin 10mg

Tesamorelin 10mg

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Tesamorelin (TH9507) is a synthetic growth hormone–releasing hormone (GHRH) analogue that selectively stimulates the pituitary to secrete growth hormone (GH). It is widely studied for its effects on IGF-1 elevation, visceral fat reduction, and metabolic profile improvement in preclinical and in vitro research models.
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Product description
Details
Research
Mechanism of Action

Tesamorelin (TH9507) is a synthetic growth hormone–releasing hormone (GHRH) analogue that selectively stimulates the pituitary to secrete growth hormone (GH). It is widely studied for its effects on IGF-1 elevation, visceral fat reduction, and metabolic profile improvement in preclinical and in vitro research models.

Researchers utilize Tesamorelin to explore GH/IGF-1 axis regulation, fat redistribution, body composition, and metabolic syndrome mechanisms. Its high specificity for GHRH receptors and well-characterized pharmacokinetics make it a reliable tool for endocrine and metabolic studies.

For Laboratory and Scientific Research Use Only. Not for Human Consumption.

Why Researchers Choose Tesamorelin

  • Highly Specific GHRH Analogue: Stimulates physiologic GH release without desensitizing pituitary receptors.

  • Metabolic Relevance: Demonstrated ability to reduce visceral adiposity and improve lipid profiles in research models.

  • Extended Half-Life: Engineered to resist DPP-IV degradation, supporting once-daily dosing studies.

  • Purity & Reliability: ≥98% peptide purity ensures reproducible experimental results.

  • Batch Verified: Identity and potency confirmed for every lot.

Important Note

For laboratory and scientific research only. Not for human consumption, veterinary use, or diagnostic purposes.

Form Lyophilized peptide powder
CAS Number 218949-48-5
Molecular Mass ~5135 Da
Chemical Formula C₂₂₁H₃₆₆N₇₂O₆₇S
Storage -20 °C (powder), -80 °C (after reconstitution)
Intended Use For preclinical and in vitro research only
Shelf Life 24 months (lyophilized)

Research Applications

GH/IGF-1 Axis Studies

Tesamorelin stimulates endogenous GH pulses, elevating serum IGF-1 levels and enabling controlled studies of GH axis regulation and feedback mechanisms【1】.

Visceral Fat & Lipid Metabolism

In preclinical and translational models, Tesamorelin has been shown to reduce visceral adipose tissue and improve triglyceride and lipid profiles, supporting research into metabolic health and adiposity【2】.

Body Composition Research

Studies indicate increased lean body mass and decreased fat mass, making Tesamorelin a valuable tool for research on sarcopenia, obesity, and metabolic modulation【3】.

Insulin Sensitivity & Metabolic Function

Some studies suggest improvements in insulin sensitivity (HOMA-IR) and glucose metabolism when GH axis activity is modulated by Tesamorelin【4】.

References

  1. Falutz J et al. (2010). Effects of Tesamorelin on Abdominal Fat and IGF-1. NEJM.

    https://academic.oup.com/jcem/article-abstract/95/9/4291/2835394
  2. Stanley TL et al. (2019). Tesamorelin Reduces Visceral Fat in Obese and HIV-Associated Lipodystrophy Models. Lancet Diabetes Endocrinol.

    https://www.natap.org/2019/HIV/PIIS2352301819303315.pdf
  3. Stanley TL et al. (2014). Changes in Body Composition with Tesamorelin. J Clin Endocrinol Metab.

    https://jamanetwork.com/journals/jama/fullarticle/1889139
  4. Falutz J et al. (2011). Metabolic Effects of Tesamorelin and GH Modulation. AIDS.

    https://peptideinfo.org/tesamorelin

Mechanism of Action (How Tesamorelin Works)

1. GHRH Receptor Activation

Tesamorelin binds to pituitary GHRH receptors, stimulating GH synthesis and promoting pulsatile GH release in laboratory and preclinical models【Falutz 2010】.

2. IGF-1 Elevation

Secreted GH acts on the liver to increase IGF-1 production, supporting anabolic processes, lean mass accrual, and tissue growth studies【Stanley 2014】.

3. Visceral Fat Reduction

Activation of the GH/IGF-1 axis enhances lipolysis, preferentially reducing visceral adipose tissue in research models of obesity and lipodystrophy【Stanley 2019】.

4. Improved Lipid Metabolism

Tesamorelin has been shown to lower triglycerides and improve lipid profiles, making it useful for metabolic and endocrinology studies【Falutz 2011】.

5. Metabolic Remodeling

Promotes protein synthesis, reduces ectopic fat deposition, and supports glucose metabolism in controlled experimental models【Stanley 2014】.

References


  1. Falutz J et al. (2010). Effects of Tesamorelin on Abdominal Fat and IGF-1. NEJM.

    https://academic.oup.com/jcem/article-abstract/95/9/4291/2835394
  2. Stanley TL et al. (2019). Tesamorelin Reduces Visceral Fat in Obese and HIV-Associated Lipodystrophy Models. Lancet Diabetes Endocrinol.

    https://www.natap.org/2019/HIV/PIIS2352301819303315.pdf
  3. Stanley TL et al. (2014). Changes in Body Composition with Tesamorelin. J Clin Endocrinol Metab.

    https://jamanetwork.com/journals/jama/fullarticle/1889139
  4. Falutz J et al. (2011). Metabolic Effects of Tesamorelin and GH Modulation. AIDS.

    https://peptideinfo.org/tesamorelin
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